Comments on: Formaldehyde link to leukemia confirmed: how to limit exposure in the home http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/ Articles on topics about sustainable living. Sat, 18 May 2013 15:28:00 +0000 hourly 1 http://wordpress.org/?v=3.5.1 By: Carole Bittman http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/comment-page-1/#comment-36197 Carole Bittman Tue, 08 May 2012 03:10:00 +0000 http://www.eartheasy.com/blog/?p=1205#comment-36197 I had a new rug installed and started getting bad reactions. Back then I did not even know the backing of new carpet causes health problems.

]]> By: John http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/comment-page-1/#comment-1948 John Thu, 18 Mar 2010 17:56:24 +0000 http://www.eartheasy.com/blog/?p=1205#comment-1948 The association between formaldehyde exposure and leukemia remains debatable. Here is new finding published on Toxi Sci online. The paper is titled "Distribution of DNA Adducts Caused by Inhaled Formaldehyde is Consistent with Induction of Nasal Carcinoma but not Leukemia" . The abstract is listed as follows:

"Inhaled formaldehyde is classified as a known human and animal carcinogen, causing nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in humans is available; however, this is inconsistent across studies. Both genotoxicty and cytotoxicity are key events in formaldehyde nasal carcinogenicity in rats, but mechanistic data for leukemia are not well established. Formation of DNA adducts is a key event in initiating carcinogenesis. Formaldehyde can induce DNA monoadducts, DNA-DNA cross-links and DNA protein cross-links. In this study, highly sensitive LC-MS/MS-SRM methods were developed and [13CD2]-formaldehyde exposures utilized, allowing differentiation of DNA adducts and DNA-DNA cross-links originating from endogenous and inhalation-derived formaldehyde exposure. The results show that exogenous formaldehyde induced N2-hydroxymethyl-dG monoadducts and dG-dG cross-links in DNA from rat respiratory nasal mucosa, but did not form [13CD2]-adducts in sites remote to the portal-of entry, even when five-times more DNA was analyzed. Furthermore, no N6-HO13CD2-dA adducts were detected in nasal DNA. In contrast, high amounts of endogenous formaldehyde dG and dA monoadducts were present in all tissues examined. The number of exogenous N2-HO13CD2-dG in 1 day and 5 day nasal DNA samples from rats exposed to 10 ppm [13CD2]-formaldehyde was 1.28±0.49 and 2.43±0.78 adducts/107 dG, respectively, while 2.63±0.73 and 2.84±1.13 N2-HOCH2-dG adducts/107 dG and 3.95±0.26 and 3.61±0.95 N6-HOCH2-dA endogenous adducts/107 dA were present. This study provides strong evidence supporting a genotoxic and cytotoxic mode of action for the carcinogenesis of inhaled formaldehyde in respiratory nasal epithelium, but does not support the biological plausibility that inhaled formaldehyde also causes leukemia."

]]> By: LorettaM http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/comment-page-1/#comment-1130 LorettaM Sat, 02 Jan 2010 03:38:06 +0000 http://www.eartheasy.com/blog/?p=1205#comment-1130 What this article fails to mention is that children and pets are often those most affected by pollutants in the home. Thank you for this helpful information. L

]]> By: Greg Seaman http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/comment-page-1/#comment-1035 Greg Seaman Sun, 13 Dec 2009 19:49:31 +0000 http://www.eartheasy.com/blog/?p=1205#comment-1035 You maught want to try spending a few days in another location to see if your allergies persist. If you find relief, then the cause is likely in your home.

]]> By: WalnutCreek http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/comment-page-1/#comment-1028 WalnutCreek Sun, 13 Dec 2009 00:09:51 +0000 http://www.eartheasy.com/blog/?p=1205#comment-1028 Since moving into our newly built home I have suffered from allergies, especially in the morning. I wonder if the building materials are the cause? Our house is sheeted with particle board and has all new furnishings and carpets. I don't know if this will diminish over time or whether I need to have the air tested in my home. Any ideas?

]]> By: chris http://eartheasy.com/blog/2009/12/formaldehyde-link-to-leukemia-confirmed-how-to-limit-exposure-in-the-home/comment-page-1/#comment-1018 chris Fri, 11 Dec 2009 02:59:08 +0000 http://www.eartheasy.com/blog/?p=1205#comment-1018 Modern homes are well sealed which contributes to the presence of indoor pollutants such as formaldehyde.

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